August 7, 2023

Seizure Latency May Help Differentiate Epileptic vs Psychogenic Nonepileptic Seizures 

Article published by AJMC


Patients with psychogenic nonepileptic seizures (PNES) experienced seizures significantly earlier than patients with epileptic seizures (ES), suggesting that seizure latency may help physicians differentiate between the seizure types. Findings from the retrospective study were published in the journal Arquivos de Neuro-Psiquiatria.

PNES and ES have similarities that can make it difficult to differentiate between them, and long-term video-electroencephalographic monitoring (VEM) is often required for differential diagnosis. In the study, researchers used VEM to investigate latency, defined as the time in hours from electroencephalogram (EEG) video recording to the first seizure, to better understand if seizure latency can aid physicians in the differential diagnosis of ES vs PNES.

“The time until seizures occur (latency) directly affects the time of the differential diagnosis,” the authors wrote. “It is an easily available quantitative value, but its contribution to the differential diagnosis of ES and PNES is not fully known.”

The researchers obtained data from a total of 497 adult patients who had been hospitalized for the differential diagnosis of ES, seizure classification, or pre-surgical evaluation over a 7-year period. Patients with other nonepileptic attacks, including syncope, hypoglycemia, cardia arrythmia, cataplexy, and movement disorders, as well as patients with concomitant ES, were excluded. After exclusion, 48 patients with PNES were diagnosed using VEM and 51 patients with ES were matched for gender and age and included in the analysis.

The authors found that seizure latency was much shorter among patients with PNES compared with patients with ES (P < .001). Additionally, 72% of patients with PNES experienced their first seizure within 24 hours of video recording compared with 49.1% of patients with ES (P = .023). Furthermore, 12.5% of patients with PNES required recording longer than 48 hours, compared with 37.3% of patients with ES (P = .006). Lastly, while ES seizures were almost evenly distributed throughout the day, most PNES seizures occurred within the evening hours (P = .011).