Featuring the work of Greg Worrell, CURE Epilepsy Grantee. Article published by Mayo Clinic.

Researchers have developed an innovative deep brain stimulation (DBS) platform that can reduce seizures and also improve memory and sleep – two common challenges for people with epilepsy. “Using an implanted investigational device, the team continuously monitored brain activity with AI-driven seizure and sleep tracking,” says Gregory Worrell, M.D., Ph.D., Mayo Clinic neurologist and co-lead author of the study. “A cloud-based platform simultaneously assessed participants’ behavior, memory, and mood at home. This real-time data enables precise tuning of stimulation settings, maximizing benefits while minimizing side effects.”

The researchers monitored five patients with temporal lobe epilepsy throughout their DBS treatment. The system, provided as part of the NIH’s BRAIN Initiative, allowed patients to track their brain activity and symptoms remotely, providing doctors with detailed, real-world data to fine-tune treatments. This technology could lead to more effective treatments for drug-resistant epilepsy and could be expanded to treat other neurological and psychiatric disorders.

“Combining neuroscience, engineering, and artificial intelligence, our work is paving the way for more personalized and effective treatments for epilepsy and other brain disorders,” says Dr. Worrell.

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