July 23, 2018

Late-Onset Epilepsy Tied to Apolipoprotein E Status

Apolipoprotein E (APOE) ?4 allele status and several potentially modifiable midlife vascular and lifestyle factors were tied to late-onset epilepsy in a prospective cohort analysis.

Midlife hypertension, diabetes, smoking, activity level, and alcohol use – in addition to APOE allele number, stroke, and dementia – were associated with later-life epilepsy, reported Emily Johnson, MD, of Johns Hopkins University School of Medicine and co-authors in JAMA Neurology.

By itself, homozygous APOE ?4 genotype roughly doubled the risk for new-onset epilepsy after age 60.

“This is the first time we have been able to identify a genetic risk for late-onset epilepsy – the apolipoprotein E4 gene,” Johnson told MedPage Today.

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