July 27, 2022

A Cross-Sectional Study of COVID-19 Vaccination Patterns Among Patients with Epilepsy in Hong Kong

Abstract found on Wiley Online Library

Objective: As Hong Kong faced the 5th wave of the COVID-19 pandemic, the facilitators and hurdles towards effective vaccination is important for healthcare professionals to understand the vaccination gap among patients with epilepsy.

Methods: A cross-sectional, pragmatic study of COVID-19 vaccination was performed at a tertiary epilepsy centre with regards to patterns of vaccination and any unusually high rate of adverse events. Patients having recent visits at the epilepsy centre (4 months) had their anonymized electronic linkage records examined 12 months after the inception of vaccination program for types of vaccines, seizure demographics, and adverse events following immunization(AEFI).

Results: 200 patients with epilepsy and their anonymized data were analyzed. The vaccine uptake was approximately 60% of that of the general population. Twice as many patients with epilepsy chose to receive mRNA vaccine as compared with inactivated vaccine. The proportion of patients who kept up-to-date with all available dosing was 7%. Patients with epilepsy with genetic aetiology were least likely to receive vaccination (13/38, 34%, p=0.02). There was no unreasonably high rate of unacceptable side effects after vaccination among patients with epilepsy. Only 3 patients reported worsening of seizures without meeting the criteria for AEFI. Refractory epilepsy, allergy to antiseizure medications and elder age (>=65) did not confer any significant difference in vaccination patterns or adverse effects.

Significance: A vaccination gap exists among epilepsy patients which calls for actionable strategies for improving vaccine uptake, including education and outreach programs.