October 21, 2022

A Companion to the Preclinical Common Data Elements for Proteomics, Lipidomics and Metabolomics Data in Rodent Epilepsy Models. A Report of the TASK3-WG4 Omics Working Group of the ILAE/AES Joint Translational Task Force

Contributors to the work include numerous CURE Epilepsy advisors, grantees, and staff

Abstract found on Wiley Online Library

The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force established the TASK3 working groups to create common data elements (CDEs) for various preclinical epilepsy research disciplines. This is the second in a two-part series of omics papers, with the other including genomics, transcriptomics and epigenomics. The aim of the CDEs is to improve the standardization of experimental designs across a range of epilepsy research related methods. We have generated CDE tables with key parameters and case report forms (CRFs) containing the essential contents of the study protocols for proteomics, lipidomics and metabolomics of samples from rodent models and people with epilepsy. We discuss the important elements that need to be considered for the proteomics, lipidomics and metabolomics methodologies, providing a rationale for the parameters that should be documented.