This was a retrospective case-control study involving patients admitted for video-EEG monitoring (VEM) over a two-year period. Clinicodemographic variables and psychometric measures of depression, anxiety, dissociation, childhood trauma, maladaptive personality traits, and cognition were recorded. Diagnosis of PNES or ES was determined by multidisciplinary assessment and consensus opinion.
Pediatric Epilepsy
Parents of children with epilepsy need support when managing epileptic seizures outside medical-care-center-settings. Previously developed training programs only provide information-based support. Therefore, within the scope of the Virtual Reality-based Seizure Management Education Program for Parents (VR-ESMEPP), a conceptual framework was developed in this study with the aim of developing parents' skills and motivation as well as providing them information regarding seizure management.
The rate of long-term mortality and number of potential years of life lost were high. Factors demonstrative of the overall situation of the patients, such as comorbidities, functional state after convulsive status epilepticus and age, were significant predictors for long-term outcome.
Pregnant women with epilepsy are more likely to have poorer sleep quality during pregnancy and postpartum compared with women with epilepsy who are not pregnant, according to study findings published in Neurology.
The diversity of Kcnq2 mouse models has proven invaluable to access neuronal networks and evaluate the associated cognitive deficits. This review summarizes the available models and their contribution to our current understanding of KCNQ2 epileptic disorders.
The functional burden of mouse neonatal hypoxia-ischemia recorded by EEG resembles closely that of the injured human newborn. The use of single-mouse longitudinal EEG in this immature model can advance our understanding of the developmental and pathophysiological mechanisms of neonatal cerebral injury and help translate novel therapeutic strategies against this devastating condition.
The predictive model, once fully developed, would spare these patients the uncertainty of not knowing when their lives would be returned to normal by taking anti-seizure medications, and possibly the harmful side-effects associated with some drugs.
This is a promising outcome suggesting that ultra-long-term low-channel EEG recordings may provide sufficient information for objective seizure diaries. Intra-individual optimization using high numbers of ictal events may further improve separation, provided that supervised learning with external validation is feasible.
Using a double electrode voltage clamp on isolated NMDA currents, we identified the most prominent antagonists of the GluN2C subunit with no effect on GluN2A as means of preventing side effects. The best compound passing through the blood-brain barrier was selected. Applied in vivo in 6 Tsc1+/- mice at P14-P17, this compound reduced or completely stopped spontaneous seizures in 4 of them, and decreased the background activity disorganization.
