In this month's update, you'll find information on a funding opportunity for SUDEP research and employment opportunities through NINDS.
Pediatric Epilepsy
Posttraumatic epilepsy (PTE) is a well-known chronic complication following traumatic brain injury (TBI). Despite some evidence that age at the time of injury may influence the likelihood of PTE, the incidence of PTE in pediatric populations remains unclear. We, therefore, conducted a systematic review to determine the overall reported incidence of PTE, and explore potential risk factors associated with PTE after pediatric TBI.
SUDEP
Patients with drug-resistant epilepsy suffer from an increased mortality rate, with the majority of deaths being epilepsy-related and 40% due to sudden unexpected death in epilepsy (SUDEP). Impact of epilepsy surgery on mortality has been investigated since the 1970s, with increased interest in this field during the past 15?years.
Featuring the work of CURE Epilepsy PTE Initiative grantee Dr. Jeffrey Loeb and his laboratory. The platform supports clinical and preclinical data management. It allows users to comprehensively visualize patient data and perform visual analytics. These utilities can improve research and clinical practice for subarachnoid hemorrhage and other brain injuries.
In this retrospective cohort, ictal changes on MRI were associated with a higher risk of neurological deterioration at discharge and, possibly, with a longer duration of SE and poorer survival.
Featuring the work of CURE Epilepsy grantee Dr. Pavel Klein. Consensus opinions report that lowering the doses of certain anti-seizure medications (ASMs) when beginning treatment with XCOPRI® (cenobamate tablets) CV may help manage possible side effects. SK Life Science, Inc. announced the publication in the journal Neurology and Therapy.
Genetics, Pediatric Epilepsy
Our September issue of Epilepsy Research News highlights research on veterans, an AI algorithm that detects brain abnormalities, seizure risk after Delta and Omicron infection, and more.
This study aimed to evaluate the surgical outcomes and relevant prognostic factors in patients with low-grade epilepsy-associated neuroepithelial tumors (LEAT) and, especially, to develop a scoring system to predict postoperative seizure outcomes.
A literature search was conducted in PubMed and Embase for studies on mechanisms of drug resistance published since 1980. The literature shows neither consensus on the definition nor a widely accepted model to explain drug resistance in IGE or one of its subsyndromes.
