“This could benefit so many children who can’t control epilepsy with drugs, which represents between 20 and 30% of children suffering from epilepsy,” said Christos Papadelis, senior author, who also serves as the director of research in the Jane and John Justin Neurosciences Center at Cook Children’s Health Care System.
Pediatric Epilepsy
In paediatric epilepsy, the evidence of effectiveness of antiseizure treatment is inconclusive for some types of epilepsy. As with other paediatric clinical trials, researchers undertaking paediatric epilepsy clinical trials face a range of challenges that may compromise external validity.
Pediatric Epilepsy
Researchers retrospectively reviewed the cases of 37 children and young adults with drug-resistant epilepsy who had undergone brain surgery at Boston Children’s Hospital. Their work concluded that noninvasive techniques to prepare for surgery could work better than existing, invasive methods.
Funding opportunities, workshops on epilepsy and PTE, and more in this Researcher Update.
Focal and generalized epilepsies are associated with robust differences in MRI measures of subcortical structures, grey matter and white matter. However, it is unknown whether such structural brain differences reflect the cause or consequence of epilepsy or its treatment.
The microbots will be able to deliver genetic material on command, enabling cell- and microcircuit-level neuromodulation in rodent brains during the later stages of the project’s development.
Pediatric Epilepsy
Status epilepticus (SE) is one of the most common neurological emergencies in children. To date, there is no definitive evidence to guide treatment of SE refractory to benzodiazepines.
Patients with highly active and ultra-refractory focal epilepsy experienced meaningful seizure outcomes on cenobamate. Emergence of adverse events at doses above 250mg/day may limit the potential for further improvements in seizure control at higher cenobamate doses.
“When we looked at other genes that handle potassium, we found that there is a major loss of these genes in tumor cells of patients that have seizures. This is very specific to patients with seizures.”
