Pediatric Epilepsy
Status epilepticus is not an uncommon neurologic emergency and depending on the associated etiology can carry significant morbidity, mortality, and cost especially if treatment is not performed in a timely manner.
SUDEP
1.11 out of 1,000 children with epilepsy die suddenly each year, according to a Canadian study by CURE grantee Dr. Elizabeth Donner.
Pediatric Epilepsy
Febrile seizures may increase the risk for subsequent epilepsy in children. Recurrent febrile seizures increased the cumulative incidence of epilepsy.
Heartbeat irregularities connected to brain activity abnormalities may lead to the ability to predict eventual epileptic seizures in subjects who suffered physical or infectious brain injuries.
SUDEP
No distinguishable autopsy findings were found between SUDEPs and epilepsy-related drownings when there were no drowning-related signs and no clear evidence of submersion.
ZX008 provided reduction in convulsive seizure frequency in the majority Lennox-Gastaut syndrome patients and was generally well tolerated.
Quality-of-life improvements for people with epilepsy depend more upon addressing psychiatric symptoms than seizures themselves.
Identifying barriers to successful delivery of effective epilepsy transition care is critical to remediating treatment care gaps and building effective future care models.
Pediatric Epilepsy
In children with brain tumors, higher seizure frequency with normal neurologic examination was more prevalent in benign tumors, whereas less frequent seizures with focal weakness and signs of increased intracranial pressure were more indicative of malignancy. Delayed onset of seizures was more often observed in the children with malignant brain tumors. Seizure characteristics play an important role in relation to tumor biology and epileptogenesis in pediatric brain tumors.
