Pediatric Epilepsy
Ovid Therapeutics Inc. announced initiations of the Phase 2 ELEKTRA and ARCADE trials for OV935/TAK-935 in pediatric patients with rare epilepsies.
Pediatric Epilepsy
Neurelis, Inc. announced that the company has submitted a New Drug Application (NDA) with the U.S. Food and Drug Administration (FDA) for VALTOCOTM (diazepam nasal spray) as a treatment for epilepsy patients six years and older who experience increased bouts of seizure activity, also known as cluster or acute repetitive seizures.
History of depression and psychosis increased risk of developing intolerable psychiatric and behavioral side effects to antiepileptic drugs. The probability of experiencing intolerable psychiatric and behavioral side effects increased for a patient taking levetiracetam or zonisamide if the patient experienced intolerable psychiatric and behavioral side effects to another antiepileptic drugs. Our results may be clinically useful for predicting intolerable psychiatric and behavioral side effects associated with certain antiepileptic drugs.
Pediatric Epilepsy
A research team led by CURE Grantee Dr. Jeong Ho Lee identified a mutation in the BRAF gene that causes intrinsic epileptogenicity in pediatric brain tumors.
The purpose of the study is to evaluate the effect of stable co-administered oxcarbazepine (OXC), on the pharmacokinetics (PK), safety, tolerability of padsevonil (PSL) and the plasma PK of PSL metabolites, UCB1431322-000 and UCB1447499-000, in study participants with epilepsy compared with study participants co-medicated with stable doses of levetiracetam (LEV), lamotrigine (LTG) or brivaracetam (BRV) therapy.
The completion of this project should permit the unveiling of a new neuronal mechanism supporting the lack of conscious experience during absences and pave the way for new clinical non-invasive strategies to interrupt ongoing seizure activity.
Becoming familiar with this new language can enable you and your doctor to better communicate about your treatment options, triggers to avoid, and what to expect in the future.
