This 50-year, long-term follow-up demonstrates a better outcome for seizure freedom compared to our follow-up after 12 years and to previous reports.
Sleep disturbances are associated with impaired memory and executive function in patients with refractory focal epilepsy and to a lesser extent, among those with medically controlled epilepsy.
This study aimed to determine if differential long-term neurodevelopmental effects exist across four commonly used AEDs (carbamazepine, lamotrigine, phenytoin, and valproate).
Genetics
Study may confirm a convergence in the genetics of common and rare epilepsies associated with ultra-rare coding variation and highlights a ubiquitous role for GABAergic inhibition in epilepsy etiology.
A new animal model could improve understanding of post-traumatic epilepsy.
Magnetic resonance thermography-guided stereotactic laser ablation was found to be an effective alternative to open surgery for epileptogenic cerebral cavernous malformations.
Genetics
Whole-exome sequencing and epilepsy panel are the most cost-effective genetic tests for epilepsy, and, for a broad population of patients with unexplained epilepsy, this research supports starting with these tests.
A substantial proportion of mothers of children with epilepsy are at risk for depression, and this risk is stable over the long term.
"Prioritizing the approval of generic drugs to compete with medicines that face little or no competition is a key part of our efforts to support access and reduce drug costs to patients," said FDA Commissioner Scott Gottlieb, MD.
