Total direct costs of Dravet Syndrome patients (excluding drugs) are driven by non-seizure-related healthcare use and high seizure burden is associated with higher healthcare costs.
This 50-year, long-term follow-up demonstrates a better outcome for seizure freedom compared to our follow-up after 12 years and to previous reports.
Sleep disturbances are associated with impaired memory and executive function in patients with refractory focal epilepsy and to a lesser extent, among those with medically controlled epilepsy.
This study aimed to determine if differential long-term neurodevelopmental effects exist across four commonly used AEDs (carbamazepine, lamotrigine, phenytoin, and valproate).
Genetics
Study may confirm a convergence in the genetics of common and rare epilepsies associated with ultra-rare coding variation and highlights a ubiquitous role for GABAergic inhibition in epilepsy etiology.
A new animal model could improve understanding of post-traumatic epilepsy.
Magnetic resonance thermography-guided stereotactic laser ablation was found to be an effective alternative to open surgery for epileptogenic cerebral cavernous malformations.
Genetics
Whole-exome sequencing and epilepsy panel are the most cost-effective genetic tests for epilepsy, and, for a broad population of patients with unexplained epilepsy, this research supports starting with these tests.
A substantial proportion of mothers of children with epilepsy are at risk for depression, and this risk is stable over the long term.
