SUDEP
Featuring the work of former CURE Epilepsy grantee Dr. Edward Glasscock.
A study that could lead to the identification of biomarkers to help identify people at risk for sudden unexpected death in epilepsy (SUDEP).
Weaning was associated with increased seizures and behavioral disturbances in a subset. An approach targeting potassium channel dysfunction with ezogabine is warranted in patients with KCNQ2-related DEE.
This study provides insight into the perspectives of users and offers recommendations for implementing automated spike and seizure detection in EMUs.
Socioeconomic hardship (increased neighborhood disadvantage) exerts a significant adverse impact on the cognitive and academic status of youth with new and recent onset epilepsies, an impact that needs to be incorporated into etiological models of the neurobehavioral comorbidities of epilepsy.
Many state-of-the-art methods for seizure prediction, using the electroencephalogram, are based on machine learning models that are black boxes, weakening the trust of clinicians in them for high-risk decisions.
If we can avoid patients not progressing to the need for IV anesthesia, intubation and an ICU stay that can sometimes be prolonged, that’s going to be lifesaving.
Genetics, Pediatric Epilepsy
The latest research on cannabidiol and seizures, the possible cause of infantile and epileptic spasms syndrome, the brain's immune system, and more in this issue of Epilepsy Research News.
Wearable automated detection devices of focal epileptic seizures are needed to alert patients and caregivers and to optimize the medical treatment. Heart rate variability (HRV)-based seizure detection devices have presented good detection sensitivity. However, false alarm rates (FAR) are too high.
They found that patients had longer-term seizure freedom when nerve pathways in the brain that link the frontal lobe to deep brain structures (the thalamus and striatum, which are responsible for relaying sensory and motor signals, motor control, emotion and reward) were disconnected - with 88% of patients seizure free after three years and 80% seizure free at five years, compared to typical outcomes for epilepsy-treating neurosurgery (30%) in the frontal lobe.
