Here, the authors describe the preclinical basis for applying interneuron transplantation to human epilepsy, discuss its potential clinical applications, and consider the translational hurdles to its development as a surgical therapy.
Pediatric Epilepsy
Initial data suggest that soticlestat continues to be safe and well tolerated and appears to reduce seizure frequency in a majority of the individual patients.
During the COVID-19 pandemic, CURE remains laser-focused on funding critically-needed research to drive science closer to a cure for epilepsy.
An increased risk of post-traumatic epilepsy is associated with higher age, moderate severity of injury, obliterated suprasellar cisterns, seizures during ICU stay and surgical care.
For her 75th birthday, CURE Champion Mary Fox hosted a 26 day virtual marathon in honor of her granddaughter who has epilepsy.
This study aimed to develop personalized forecasts from a mobile seizure diary app, since seizure cycles can be measured using a range of recording modalities.
Pregabalin 14 mg/kg/d (but not 7 mg/kg/d) significantly reduced seizure rate in children with focal-onset seizures, when assessed using V?EEG, compared with placebo.
Doctors may be missing an opportunity to develop preventive treatment for epilepsy by not evaluating potentially “repurposable” medications clinically.
See what updates and discoveries our grantees have made as part of this initiative to find ways to study PTE and, ultimately, prevent it.
