Approximately one-third of people living with epilepsy are unable to obtain seizure control with the currently marketed antiseizure medications (ASMs), creating a need for novel therapeutics with new mechanisms of action.
Having subtler symptoms, a form of epilepsy that affects only one part of the brain often goes undiagnosed long enough to cause unexpected seizures that contribute to car crashes, a new study finds.
Pharmacoresistance and the lack of disease?modifying actions of current antiseizure drugs persist as major challenges in the treatment of epilepsy. The aim of the present study was to compare the molecular landscape of the intra?amygdala kainic acid model of status epilepticus in mice with findings in resected brain tissue from patients with drug?resistant temporal lobe epilepsy (TLE).
The COVID-19 pandemic and related lockdown measures drastically changed health care and emergency services utilization. This study evaluated trends in emergency department (ED) access for seizure-related reasons in the first 8 weeks of lockdown in Italy.
Advances in gene discovery have identified genetic variants in the solute carrier family 6 member 1 (SLC6A1) gene as a monogenic cause of neurodevelopmental disorders, including epilepsy with myoclonic atonic seizures, autism spectrum disorder, and intellectual disability.
Formerly-known as Citizens United for Research in Epilepsy (CURE), we have rebranded to CURE Epilepsy.
Our name has changed: we are now CURE Epilepsy. Don't miss these updates and other opportunities within the field!
Guidelines on antiepileptic treatment are limited to the first treatment attempts, leaving many degrees of freedom in later stages of treatment. This study sought to ascertain factors that are related to the antiepileptic drug load in epilepsy.
To assess prognostic patterns and investigate clinical and electroencephalography (EEG) variables associated with persistent treatment resistance in a population of genetic generalized epilepsy (GGE) patients with a long?term follow?up.
