New strategies for the treatment of medically intractable epilepsy are desperately needed. Cell-based transplantation is slowly emerging as a real therapeutic possibility, although many barriers remain. Dr. Goldberg proposes to use specific, defined subtypes of cortical interneuron precursors to treat epilepsy and its comorbidities in an experimental model of acquired chronic temporal lobe epilepsy. They will assess the functional integration of transplanted interneurons into normal and epileptic hippocampus as well as the ability of such cells to correct circuit-level dysfunction seen in epileptic brain circuits. They will also test the efficacy of transplanted cells in reducing or eliminating seizures in this preclinical model.
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