Prevention of Acquired Epilepsies Awards

The Contributions Of CD74 To Acquired Epilepsy

Karen Newell-Rogers, PhD - Lee Shapiro, PhD
Texas A&M University System Health Science Center

Epilepsy occurs in 15 to 20% of traumatic brain injuries. Who acquires post-traumatic epilepsy (PTE), and why, is unknown. While injury type and severity influence who gets epilepsy, similar injuries can cause PTE in one person, but not in another. The answer to why similar injuries can have such different outcomes may lie in the differences between individuals’ immune responses. TBI causes inflammation and can elicit an immune response. We have also discovered that targeting components of the immune response can suppress inflammation after TBI. The purpose of this proposal is to determine if we can prevent PTE by selectively targeting a damaging immune response after TBI.


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