Temporal lobe epilepsy is a major public health problem because it is both common and frequently resistant to treatment. There is no effective prevention. Src family kinases (SFKs) are a family of signaling molecules that have been implicated in diverse physiological and pathological conditions. Experimental evidence has led to the hypothesis that SFKs promote epileptogenesis in vivo. In this project, I will use biochemistry and mouse genetics to investigate the role of SFKs in epileptogenesis. These findings will hopefully elucidate some of the molecular signaling mechanisms underlying epileptogenesis and identify novel molecular targets for prevention of temporal lobe epilepsy.
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