Drug resistant seizures are common in epilepsy, and these events directly contribute to premature death and reduce the quality of life for a significant proportion of patients. We believe these so-called “pharmacoresistant” seizures result from a failure in neuronal inhibition, due in part to abnormal intracellular accumulation of chloride. Here we will test the ability of recently identified pharmacological agents that are able to normalize intracellular chloride levels, to terminate pharmacoresistant seizures in rodents. Collectively these studies may lead to the development of novel ther.
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