Traumatic Brain Injury Awards

Prevention of Post-Traumatic Epilepsy by Transient Modulation of Adenosine Receptors

Detlev Boison, PhD
R.S. Dow Neurobiology Labs

Adenosine is one of the brain’s own seizure-control substances and recent evidence suggests that epilepsy development is associated with a failure in the adenosine system. A frequent cause for the development of epilepsy is a previous traumatic brain injury. In this two-year study, Dr. Boison will examine how failures in the adenosine system develop as a consequence of brain injury, how these failures contribute to the development of spontaneous recurrent seizures, and how the development of epilepsy can be prevented by transient application of adenosine-related drugs during a critical window of time after the injury.


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