Advances in epilepsy surgery and the advent of implantable brain devices which predict the onset of seizures and administer treatment, require greater accuracy in pinpointing the exact location where seizures begin. Dr. Worrell’s study of the usefulness of high-frequency epileptiform oscillations to more accurately locate the area of the brain involved in the seizure, is a unique collaboration combining the neuroengineering strength of the University of Pennsylvania with Mayo Clinic’s large surgical epilepsy practice, translating engineering advances into clinical practice.