Quest Awards

Anaplerosis: A Potential New Dietary Therapy For Epilepsy

Karin Borges, PhD
Texas Tech University Health Sciences Center, Amarillo, TX

Many patients with epilepsy do not respond to drugs or to the high-fat ketogenic diet. Triheptanoin, a tasteless and well-tolerated oil, is a component of the anaplerotic diet. This oil is believed to provide more energy to the brain, which may help to stabilize nerve cell activity and prevent seizures. In this one-year study, Dr. Borges will test, in mice, whether an anaplerotic diet can inhibit seizures. If so, this study could lay the groundwork for future investigation of this novel approach to treating epilepsy.


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