CURE Award, Funded by the Rhode Island Award

A Role For The mTOR Pathway In NMDA Receptor Mediated Epileptogenesis: A Molecular Investigation Of Protein Interactions

Children’s Hospital & Harvard Medical School, Boston, MA

2006 Nikolaus J. Sucher, MD

The Rhode Island Award

The NMDA receptor is crucial for the normal function of the brain. The receptor is a protein complex that is composed of multiple subunits, some of which may be critical for the development of epilepsy in patients with Tuberous Sclerosis (TSC). This study will investigate the molecular details of the interaction and function of selected proteins, which may suggest novel targets for the treatment of TSC and epilepsy.