The rates of childhood epilepsy in malaria prone regions of the developing world are substantially higher than in industrialized countries. Although epilepsy is well described as a consequence of cerebral malaria, we do not understand how to prevent these large numbers of people, mostly children, from developing epilepsy after cerebral malaria. This project represents a multidisciplinary effort of an epilepsy specialist, a malaria biologist, an experimental physicist, a malaria clinician, and an optical imaging expert towards exploring several likely mechanisms at preventing post-malarial epilepsy. Our translational approach focuses on fusing fundamental biology and clinical principles to help guide future human clinical trials.